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Compound / Phase
Research Pre-clinical Clinical
Aramchol                    
Steamchol
New derivatives


The most advanced compound is Aramchol (arachidyl amido cholanoic acid), which is currently approaching the clinical phase.         Steamchol (stearoyl amido cholanoic acid) is in the process of entering pre-clinical studies.

Cholesterol Metabolism & Atherosclerosis
In several series of experiments in various strains of mice or in hamsters in which hypercholesterolemia was induced either by excessive dietary intake or by increased synthesis, oral Aramchol markedly and significantly reduced plasma cholesterol as compared to saline treated controls. In some of these studies the reduction was to levels lower than those found in comparable animals on a regular diet. The effects on plasma cholesterol levels were observed both in animals that have received ARMCHOL together with the high fat diets as well as in animals that were initially primed to have hypercholesterolemia and subsequently treated with Aramchol. These effects of Aramchol in mice were confirmed in 3 series of experiments in hamsters. In these experiments hypercholesterolemia was induced by diet or by stimulation of endogenous synthesis. Aramchol reduced the high cholesterol levels more than simvastatin and similar or more than atorvastatin.

Fatty Liver (NAFLD)
Aramchol, given orally, was demonstrated to prevent diet induced fatty liver in several animal species, using different diets (Hepatology 2003; 38:346). More recently we have also shown that they also reduce preexisting diet induced fatty liver; i.e. they are effective in a therapeutic setting (unpublished). The rapidity and the magnitude of the therapeutic effect (weeks or months) are inversely proportional to the fat concentration in the maintenance diet during the treatment period.The molecular mechanism has been elucidated 

Cholesterol Gallstones
Aramchol was shown to both prevent and dissolve preformed gallstones in numerous in vivo experiments (Gut 2001; 48:75, Lipids 2001; 36:1135, Hepatology 2002; 35:597). The extent of the dissolution was dose-dependent and in the majority of experiments, a full elimination of gallstones was obtained.The molecular mechanism of the effect has been elucidated.

 
 

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